ML 279 |CAS:1604821-55-7 Probechem Biochemicals

Chemical Structure : ML 279

ML 279 (ML279)

Catalog No.: PC-62105Not For Human Use, Lab Use Only.

ML279 is a potent and reversible inhibitor of lipid uptake via SR-BI (scavenger receptor BI) with IC50 of 17 nM.

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Biological Activity

ML279 is a potent and reversible inhibitor of lipid uptake via SR-BI (scavenger receptor BI) with IC50 of 17 nM.
ML279 stabilizes the interaction of HDL particles with SR-BI, and is non-toxic, plasma stable, and has improved solubility over alternative probe ML278.

Physicochemical Properties

M.Wt	468.55
Formula	C24H32N6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(2-(5-(benzo[d][1,3]dioxol-5-yl)-2H-tetrazol-2-yl)-N-cyclohexylacetamido)-N-cyclopentylpropanamide

References

1. Dockendorff C, et al. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2594-8.

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ML 279 (ML279)

Biological Activity

Physicochemical Properties

References

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