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ML 279

Chemical Structure : ML 279

CAS No.: 1604821-55-7

ML 279 (ML279)

Catalog No.: PC-62105Not For Human Use, Lab Use Only.

ML279 is a potent and reversible inhibitor of lipid uptake via SR-BI (scavenger receptor BI) with IC50 of 17 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML279 is a potent and reversible inhibitor of lipid uptake via SR-BI (scavenger receptor BI) with IC50 of 17 nM.
ML279 stabilizes the interaction of HDL particles with SR-BI, and is non-toxic, plasma stable, and has improved solubility over alternative probe ML278.

Physicochemical Properties

M.Wt 468.55
Formula C24H32N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-(2-(5-(benzo[d][1,3]dioxol-5-yl)-2H-tetrazol-2-yl)-N-cyclohexylacetamido)-N-cyclopentylpropanamide

References

1. Dockendorff C, et al. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2594-8.

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