ML283

Chemical Structure : ML283

Catalog No.: PC-24071Not For Human Use, Lab Use Only.

ML283 is a potent, specific inhibitor of HCV non-structural protein 3 (NS3) helicase with IC50 of 2.6 uM (HCV genotype 1b), also inhibits DENV NS3-catalyzed RNA unwinding, also is a potent SARS-CoV-2 nsp13 helicase inhibitor.

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Biological Activity

Physicochemical Properties

M.Wt	609.13
Formula	C28H21ClN4O4S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	[2,6'-Bibenzothiazole]-7-sulfonic acid, 2'-[4-[(3-chlorobenzoyl)amino]phenyl]-6-methyl-, ammonium salt (1:1)

References

1. Sweeney NL, et al. ACS Infect Dis. 2015 Mar 13;1(3):140-148.

2. Li K, et al. Hepatitis C Virus NS3 Helicase Inhibitor Discovery.

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ML283

Biological Activity

Physicochemical Properties

References

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