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Chemical Structure : ML297
CAS No.: 1443246-62-5
Catalog No.: PC-70331Not For Human Use, Lab Use Only.
ML297 (VU 0456810) is a potent, selective, CNS-penetrant small molecule agonist of GIRK channels with EC50 of 160 nM.
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|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
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ML297 (VU 0456810) is a potent, selective, CNS-penetrant small molecule agonist of GIRK channels with EC50 of 160 nM.
ML297 shows a preference for the GIRK1/GIRK2 subunit combination compared to GIRK1/GIRK4 and is inactive on GIRK2/GIRK3 and a number of other potassium channels.
ML297 selectively activates recombinant neuronal GIRK channels containing the GIRK1 subunit in a manner that requires PIP2.
ML297 decreases anxiety-related behavior without sedative or addictive liabilities in mice.
| M.Wt | 328.32 | |
| Formula | C17H14F2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea |
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1. Wydeven N, et al. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10755-60.
2. Kaufmann K, et al. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86.
3. Psichas A, et al. Br J Pharmacol. 2016 Mar;173(5):888-98.
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