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Chemical Structure : ML299
CAS No.: 1426916-00-8
Catalog No.: PC-62136Not For Human Use, Lab Use Only.
ML299 (VU0463568) is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe inhibitor with IC50 of 6 nM/20 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote |
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ML299 (VU0463568) is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe inhibitor with IC50 of 6 nM/20 nM, respectively.
ML299 (VU0463568) robustly increases caspase 3/7 activation under serum-free conditions, provides a dose-dependent decrease (100 nM to 10 uM) in invasive migration in U87-MG cells, with statistical significance reached at both the 1 uM and 10 uM doses.
| M.Wt | 489.4 | |
| Formula | C23H26BrFN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]-benzamide |
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1. Scott SA, et al. Nat Chem Biol. 2009 Feb;5(2):108-17.
2. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9.
3. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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