Chemical Structure : ML299
CAS No.:
1426916-00-8
ML299
(VU0463568; ML-299)
Catalog No. : PC-62136Not For Human Use, Lab Use Only.
ML299 (VU0463568) is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe inhibitor with IC50 of 6 nM/20 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6213601
Biological Activity
ML299 (VU0463568) is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe inhibitor with IC50 of 6 nM/20 nM, respectively.
Physicochemical Properties
M.Wt
489.4
Formula
C23H26BrFN4O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]-benzamide
References
1. Scott SA, et al. Nat Chem Biol.
2. O'Reilly MC, et al. J Med Chem.
3. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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