ML301 | NTR1 agonist | Probechem Biochemicals

Chemical Structure : ML301

ML301 (ML 301)

Catalog No.: PC-20492Not For Human Use, Lab Use Only.

ML301 is a selective full (79-93%) neurotensin-1 (NTR1) receptor agonist with EC50 of 2.0-4.1 uM, good selectivity relative to NTR2 and GPR35.

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Biological Activity

ML301 is a selective full (79-93%) neurotensin-1 (NTR1) receptor agonist with EC50 of 2.0-4.1 uM, good selectivity relative to NTR2 and GPR35.
ML301 showed good activity in a Ca mobilization FLIPR assay (93% efficacy at 298 nM), consistent with it functioning via the Gq coupled pathway.

Physicochemical Properties

M.Wt	522.99
Formula	C27H27ClN4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	CC(C)C[C@@H](C(O)=O)NC(C1=CN(C2=CC=NC3=CC(Cl)=CC=C23)C(C4=C(OC)C=CC=C4OC)=N1)=O

References

1. Hershberger PM, et al. Bioorg Med Chem Lett. 2014 Jan 1;24(1):262-7.

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ML301 (ML 301)

Biological Activity

Physicochemical Properties

References

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