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ML303

Chemical Structure : ML303

CAS No.: 1638211-04-7

ML303 (ML 303)

Catalog No.: PC-38457Not For Human Use, Lab Use Only.

ML303 is a potent, specific influenza virus non structural 1 (NS1) antagonist, shows potent reduction of viral titer in MDCK cells infected with the Influenza A/PR/8/34 strain with IC90 of 155 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML303 is a potent, specific influenza virus non structural 1 (NS1) antagonist, shows potent reduction of viral titer in MDCK cells infected with the Influenza A/PR/8/34 strain with IC90 of 155 nM.
ML303 specifically restored the NS1-inhibited expression of the interferon mRNA, inhibited the NS1 function in mechanistic assay and exhibited a potent antiviral activity in culture.

Physicochemical Properties

M.Wt 399.373
Formula C21H16F3N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol

References

1. Samarjit Patnaik, et al. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

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