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Chemical Structure : ML308
CAS No.: 1212238-62-4
Catalog No.: PC-20702Not For Human Use, Lab Use Only.
ML308 (ML 308) is a potent, selective inhibitor of two-pore domain potassium channel KCNK9 (TASK-3, K2P9.1) with IC50 of 130 nM in thallium influx fluorescent assays and 413 nM in automated electrophysiology assays, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $758 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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ML308 (ML 308) is a potent, selective inhibitor of two-pore domain potassium channel KCNK9 (TASK-3, K2P9.1) with IC50 of 130 nM in thallium influx fluorescent assays and 413 nM in automated electrophysiology assays, respectively.
ML308 displays >50-fold selectivity over the closely-related, two-pore domain potassium channel, KCNK3, in fluorescent assays and displays little or no activity at 10 μM for Kir2.1, KCNQ2, and human ether-a go-go-related gene (HERG).
ML308 is a useful pharmacological probe for in vitro studies of KCNK9 function.
| M.Wt | 289.40 | |
| Formula | C15H19N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
SC1=NN=C(C2=CC=CO2)N1[C@H]([C@H]3[C@](C4)([H])CC[C@]4([H])C3)C |
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1. Miller MR, et al. National Center for Biotechnology Information (US); 2010–.
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