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ML309

Chemical Structure : ML309

CAS No.: 1355446-05-7

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ML309 (ML 309, ML-309)

Catalog No.: PC-62686Not For Human Use, Lab Use Only.

ML309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM, displays >380-fold selectivity over wt IDH1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM, displays >380-fold selectivity over wt IDH1.
    ML309 reduces cell-based production of 2-HG in a U87MG mutant glioblastoma cell line (IC50=509 nM) and show no cytotoxicity.
    ML309 has good in vitro ADME and in vivo PK profile.

    Physicochemical Properties

    M.Wt 484.575
    Formula C29H29FN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-(1H-benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclopentyl-2-(o-tolyl)acetamide

    References

    1. Merk A, et al. Cell. 2016 Jun 16;165(7):1698-707.

    2. Davis M, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

    3. Davis MI, et al. J Biol Chem. 2014 May 16;289(20):13717-25.

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