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ML309 hydrochloride

Chemical Structure : ML309 hydrochloride

CAS No.: 1355327-02-4

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ML309 hydrochloride (ML 309 )

Catalog No.: PC-62685Not For Human Use, Lab Use Only.

ML 309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML 309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM; displays >380-fold selectivity over wt IDH1; reduces cell-based production of 2-HG in a U87MG mutant glioblastoma cell line (IC50=509 nM) and show no cytotoxicity; has good in vitro ADME and in vivo PK profile.

Physicochemical Properties

M.Wt 521.033
Formula C29H30ClFN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-(1H-benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclopentyl-2-(o-tolyl)acetamide hydrochloride

References

1. Merk A, et al. Cell. 2016 Jun 16;165(7):1698-707.

2. Davis M, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

3. Davis MI, et al. J Biol Chem. 2014 May 16;289(20):13717-25.

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