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Chemical Structure : ML314
CAS No.: 1448895-09-7
Catalog No.: PC-20493Not For Human Use, Lab Use Only.
ML314 is a selective, brain penetrant full agonist of neurotensin 1 receptor (NTR1) with EC50 of 2.0 uM, shows good selectivity against NTR2 and GPR35.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 25 mg | $388 | In stock | |
| 100 mg | $898 | In stock | |
| 1 g | Get quote |
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ML314 is a selective, brain penetrant full agonist of neurotensin 1 receptor (NTR1) with EC50 of 2.0 uM, shows good selectivity against NTR2 and GPR35.
ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway.
| M.Wt | 420.51 | |
| Formula | C24H28N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
COC1=CC=CC=C1N2CCN(C3=C4C=C(OC)C(OC)=CC4=NC(C5CC5)=N3)CC2 |
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1. Peddibhotla S, et al. ACS Med Chem Lett. 2013 Jul 20;4(9):846-851.
2. Barak LS, et al. ACS Chem Biol. 2016 Jul 15;11(7):1880-90.
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