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ML314

Chemical Structure : ML314

CAS No.: 1448895-09-7

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ML314 (ML 314)

Catalog No.: PC-20493Not For Human Use, Lab Use Only.

ML314 is a selective, brain penetrant full agonist of neurotensin 1 receptor (NTR1) with EC50 of 2.0 uM, shows good selectivity against NTR2 and GPR35.

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5 mg $118 In stock
10 mg $188 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML314 is a selective, brain penetrant full agonist of neurotensin 1 receptor (NTR1) with EC50 of 2.0 uM, shows good selectivity against NTR2 and GPR35.
ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway.

Physicochemical Properties

M.Wt 420.51
Formula C24H28N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline

References

1. Peddibhotla S, et al. ACS Med Chem Lett. 2013 Jul 20;4(9):846-851.

2. Barak LS, et al. ACS Chem Biol. 2016 Jul 15;11(7):1880-90.

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