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ML325

Chemical Structure : ML325

CAS No.: 110144-34-8

ML325 (ML 325)

Catalog No.: PC-20331Not For Human Use, Lab Use Only.

ML325 (ML 325) is a potent, irreversible pan-protein arginine deiminase (PAD) inhibitor with IC50 of 70 nM, 200 nM 170 nM, and 240 nM for PAD1, 2, 3, and 4 in vitro respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML325 (ML 325) is a potent, irreversible pan-protein arginine deiminase (PAD) inhibitor with IC50 of 70 nM, 200 nM 170 nM, and 240 nM for PAD1, 2, 3, and 4 in vitro respectively.
    ML325 has kinact/KI values of 3500, 7300, 1900, and 5300 M−1min−1 for PAD1, 2, 3 and 4 respectively, 4-fold selectivity among the four family members.
    ML325 exhibits high selectivity over > 20 cysteine-reactive proteins as assayed by activity-based protein profiling.

    Physicochemical Properties

    M.Wt 295.25
    Formula C15H9N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-(7-amino-5,8-dioxo-5,8-dihydroquinolin-2-yl)picolinic acid

    References

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