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Chemical Structure : ML336
CAS No.: 1613465-33-0
Catalog No.: PC-38481Not For Human Use, Lab Use Only.
ML336 is a highly potent small molecule inhibitor of enezuelan equine encephalitis virus (VEEV) with EC50 of 0.02-0.04 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $238 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ML336 is a highly potent small molecule inhibitor of enezuelan equine encephalitis virus (VEEV) with EC50 of 0.02-0.04 uM.
ML336 potently inhibits VEEV RNA synthesis with IC50 of 1.1 nM, but not Old World alphavirus Chikungunya virus (IC50>4 uM).
ML336 inhibits the synthesis of the positive sense genomic, negative sense template, and subgenomic RNAs of VEEV. ML336 shows significant protection and inhibits viral replication in vivo in VEEV-infected mice (5 mg/kg/day).
ML336 appears to inhibit viral replication through a unique pathway involving interference with viral nonstructural proteins 2 and 4, or inhibits viral RNA synthesis through interaction with the viral replicase complex.
| M.Wt | 367.409 | |
| Formula | C19H21N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide |
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1. Schroeder CE, et al. J Med Chem. 2014 Oct 23;57(20):8608-21.
2. Chung D, et al. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.
3. Jonsson CB, et al. Antiviral Res. 2019 Jul;167:25-34.
4. Skidmore AM, et al. Antiviral Res. 2020 Feb;174:104674.
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