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ML348

Chemical Structure : ML348

CAS No.: 899713-86-1

ML348 (ML-348, GNF-Pf-1127)

Catalog No.: PC-42240Not For Human Use, Lab Use Only.

ML348 is a potent, selective Acyl protein thioesterase 1 (APT-1, LYPLA1) with IC50 of 210 nM, displays >10-fold selectivity over APT-2, >47-fold selectivity over a panel of >20 serine hydrolases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML348 is a potent, selective Acyl protein thioesterase 1 (APT-1, LYPLA1) with IC50 of 210 nM, displays >10-fold selectivity over APT-2, >47-fold selectivity over a panel of >20 serine hydrolases.
ML348 shows no biologically significant effects in NRAS mutant melanoma cells.

Physicochemical Properties

M.Wt 415.7941
Formula C18H17ClF3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-

References

1. Adibekian A, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Vujic I, et al. Oncotarget. 2016 Feb 9;7(6):7297-306.

3. Won SJ, et al. ACS Chem Biol. 2016 Dec 16;11(12):3374-3382.

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