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Chemical Structure : ML348
CAS No.: 899713-86-1
Catalog No.: PC-42240Not For Human Use, Lab Use Only.
ML348 is a potent, selective Acyl protein thioesterase 1 (APT-1, LYPLA1) with IC50 of 210 nM, displays >10-fold selectivity over APT-2, >47-fold selectivity over a panel of >20 serine hydrolases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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ML348 is a potent, selective Acyl protein thioesterase 1 (APT-1, LYPLA1) with IC50 of 210 nM, displays >10-fold selectivity over APT-2, >47-fold selectivity over a panel of >20 serine hydrolases.
ML348 shows no biologically significant effects in NRAS mutant melanoma cells.
| M.Wt | 415.7941 | |
| Formula | C18H17ClF3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)- |
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1. Adibekian A, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Vujic I, et al. Oncotarget. 2016 Feb 9;7(6):7297-306.
3. Won SJ, et al. ACS Chem Biol. 2016 Dec 16;11(12):3374-3382.
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