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Chemical Structure : ML349
CAS No.: 890819-86-0
Catalog No.: PC-60917Not For Human Use, Lab Use Only.
ML349 is a potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | Get quote |
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ML349 is a potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM.
ML349 displays >20-fold selectivity over APT-1 and serine hydrolase enzyme family.
ML349 is an useful chemical probe for investigations into the biological function of LYPLA1 and LYPLA2.
| M.Wt | 454.56 | |
| Formula | C23H22N2O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 20 mg/mL |
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| Chemical Name/SMILES |
(5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone |
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1. Won SJ, et al. ACS Chem Biol. 2016 Dec 16;11(12):3374-3382.
2. Vujic I, et al. Oncotarget. 2016 Feb 9;7(6):7297-306.
3. Won SJ, et al. ACS Med Chem Lett. 2016 Dec 9;8(2):215-220.
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