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Chemical Structure : ML350
Catalog No.: PC-62111Not For Human Use, Lab Use Only.
ML350 (CYM 50202) is a highly potent and selective Opioid kappa receptor (OPRK1/KOR) antagonist with IC50 of 9-16 nM.
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ML350 (CYM 50202) is a highly potent and selective Opioid kappa receptor (OPRK1/KOR) antagonist with IC50 of 9-16 nM; displays 219-382–fold and 20-35–fold selectivity over OPRD1 and OPRM1, respectively; has high passive membrane permeability, good brain penetration, no significant activity at three of four human cytochrome P450 subtypes, high binding for rodent plasma protein and modest binding for human plasma protein, and an encouraging in vivo pharmacokinetic profile in rats; has a reversible analgesic effect when challenged with an OPRK agonist (U-69593) in a tail flick assay in mice.
| M.Wt | 412.328 | |
| Formula | C18H26BrN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guerrero M, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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