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ML355

Chemical Structure : ML355

CAS No.: 1532593-30-8

ML355 (VLX-1005, ML-355, VLX1005)

Catalog No.: PC-42990Not For Human Use, Lab Use Only.

ML355 (VLX-1005) is a potent, and selective inhibitor of human 12-Lipoxygenase (12-LOX) with IC50 of 290 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML355 (VLX-1005) is a potent, and selective inhibitor of human 12-Lipoxygenase (12-LOX) with IC50 of 290 nM.
ML355 displays >100-fold selectivity over 15-LOX-1, 15-LOX-2, 5-LOX and COX1, COX2.
ML355 has favorable ADME properties, inhibits PAR-4 induced aggregation and calcium mobilization in human platelets, and reduces 12-HETE in mouse/human beta cells.

Physicochemical Properties

M.Wt 441.5233
Formula C21H19N3O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 42 mg/mL

Chemical Name/SMILES

Benzenesulfonamide, N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-

References

1. Luci D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Ma K, et al. J Clin Endocrinol Metab. 2017 May 10. doi: 10.1210/Jc.2017-00267.

3. Luci DK, et al. J Med Chem. 2014 Jan 23;57(2):495-506.

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