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ML356

Chemical Structure : ML356

CAS No.: 1808260-45-8

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ML356 (ML-356)

Catalog No.: PC-28554Not For Human Use, Lab Use Only.

ML356 is a potent, selective inhibitor of the thioesterase (TE) domain of fatty acid synthase (FASN, FAS) (FASN-TE) with IC50 of 0.334 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML356 is a potent, selective inhibitor of the thioesterase (TE) domain of fatty acid synthase (FASN, FAS) (FASN-TE) with IC50 of 0.334 uM.
ML356 is selective for FAS over a number of other human thioesterases expressed in tumor cells, and selective for the thioesterase domain of FAS over its most closely related human homolog, ACOT4.
ML356 blocks the biosynthesis of palmitate (the end product of FAS) in cells.

Physicochemical Properties

M.Wt 423.55
Formula C19H25N3O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Ethyl-N-(4-(4-(morpholinosulfonyl)phenyl)thiazol-2-yl)butanamide

References

1. Robert Ardecky, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2013 Apr 12 [updated 2014 Jan 13].

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