ML375 |CAS:1488362-55-5 Probechem Biochemicals

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Chemical Structure : ML375

ML375 (VU-0483253, VU0483253)

Catalog No.: PC-62746Not For Human Use, Lab Use Only.

ML375 (VU0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML375 (VU0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM).
ML375 exhibts excellent multispecies PK, high CNS penetration, and enantiospecific inhibition.

Physicochemical Properties

M.Wt	424.832
Formula	C23H15ClF2N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one

References

1. Gentry PR, et al. J Med Chem. 2013 Nov 27;56(22):9351-5.

2. Berizzi AE, et al. Mol Pharmacol. 2016 Oct;90(4):427-36.

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ML375 (VU-0483253, VU0483253)

Biological Activity

Physicochemical Properties

References

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