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Chemical Structure : ML375
Catalog No.: PC-62746Not For Human Use, Lab Use Only.
ML375 (VU0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM).
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ML375 (VU0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM).
ML375 exhibts excellent multispecies PK, high CNS penetration, and enantiospecific inhibition.
| M.Wt | 424.832 | |
| Formula | C23H15ClF2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gentry PR, et al. J Med Chem. 2013 Nov 27;56(22):9351-5.
2. Berizzi AE, et al. Mol Pharmacol. 2016 Oct;90(4):427-36.
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