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ML378

Chemical Structure : ML378

CAS No.: 1831135-21-7

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ML378 (CID71710938;JJH-254)

Catalog No.: PC-62332Not For Human Use, Lab Use Only.

ML378 (CID71710938, JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML378 (CID71710938, JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively.
    ML378 also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively.

    Physicochemical Properties

    M.Wt 534.01
    Formula C25H32ClN5O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-(Morpholine-4-carbonyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-chloro-phenethyl)piperidine-1-carboxylate

    References

    1. Hulce JJ, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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