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Chemical Structure : ML381 fumarate
Catalog No.: PC-62144Not For Human Use, Lab Use Only.
ML381 (VU0488130) is a highly mAChR subtype selective M5 orthosteric antagonist with IC50/Ki of 450/340 nM for hM5, has no inhibitory activity on hM1-4 (IC50>30 uM).
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ML381 (VU0488130) fumarate is a highly mAChR subtype selective M5 orthosteric antagonist with IC50/Ki of 450/340 nM for hM5, has no inhibitory activity on hM1-4 (IC50>30 uM).
ML381 exhibits good DMPK properties and CNS penetration (B:P ratio of 0.58) to support both in vitro and in vivo studies.
| M.Wt | 495.488 | |
| Formula | C25H25N3O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gentry PR, et al. ChemMedChem. 2014 Aug;9(8):1677-82.
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