ML389 | V1AR antagonist | Probechem Biochemicals

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Chemical Structure : ML389

ML389 (ML 389)

Catalog No.: PC-62116Not For Human Use, Lab Use Only.

ML389 is a highly potent, selective vasopressin receptor 1a (V1a-R) antagonist with IC50 of 40 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML389 is a highly potent, selective vasopressin receptor 1a (V1a-R) antagonist with IC50 of 40 nM.
ML389 dispalys >1,250-fold selectivity over V1b-R, V2-R, and OXTR.
ML389 has good brain penetration, no significant activity at four human cytochrome P450 subtypes, high binding for human and rodent plasma protein, and an encouraging in vivo pharmacokinetic profile in mice.

Physicochemical Properties

M.Wt	404.33
Formula	C21H23Cl2N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorophenyl)-1-(5-chloropyridin-2-yl)-N-(cyclopropylmethyl)piperidine-4-carboxamide

References

1. Mittapalli G, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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ML389 (ML 389)

Biological Activity

Physicochemical Properties

References

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