Catalog No.: PC-62138Not For Human Use, Lab Use Only.
ML395 is a potent, selective, allosteric phospholipase D2 (PLD2) inhibitor with cellular IC50 of 360 nM, shows >80-fold selectivity over PLD1 (IC50>30 uM).
ML395 (VU0468809) is a potent, selective, allosteric phospholipase D2 (PLD2) inhibitor with cellular IC50 of 360 nM, shows >80-fold selectivity over PLD1 (IC50>30 uM).
ML395 (VU0468809) displays exceptional solubility, stability and PK; an improvement over the first generation PLD2 selective inhibitor, ML298.
ML395 (VU0468809) is an useful tool to probe selective PLD2 function in vitro and in vivo, demonstrates broad-spectrum antiviral activity in cellular assays against a range of influenza strains (H1, H3, H5 and H7).
