Catalog No.: PC-62135Not For Human Use, Lab Use Only.
ML404 is a small molecule inhibitor of mitochondrial permeability transition pore (mtPTP, mPTP), inhibits mitochondrial swelling with EC50 of 4.9 nM, shows no effect on mitochondrial coupling at >100 uM.
ML404 is a small molecule inhibitor of mitochondrial permeability transition pore (mtPTP, mPTP), inhibits mitochondrial swelling with EC50 of 4.9 nM, shows no effect on mitochondrial coupling at >100 uM.
ML404 increases the calcium retention capacity (CRC) of mitochondria (a measure of mtPTP inhibition) 14.8-fold at 12.5 uM, a concentration that does not affect mitochondrial respiration at which the compound appears non-toxic.
ML404 is 2.3-fold more effective inhibitor than GNX-865.
