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Chemical Structure : ML404
Catalog No.: PC-62135Not For Human Use, Lab Use Only.
ML404 is a small molecule inhibitor of mitochondrial permeability transition pore (mtPTP, mPTP), inhibits mitochondrial swelling with EC50 of 4.9 nM, shows no effect on mitochondrial coupling at >100 uM.
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ML404 is a small molecule inhibitor of mitochondrial permeability transition pore (mtPTP, mPTP), inhibits mitochondrial swelling with EC50 of 4.9 nM, shows no effect on mitochondrial coupling at >100 uM.
ML404 increases the calcium retention capacity (CRC) of mitochondria (a measure of mtPTP inhibition) 14.8-fold at 12.5 uM, a concentration that does not affect mitochondrial respiration at which the compound appears non-toxic.
ML404 is 2.3-fold more effective inhibitor than GNX-865.
| M.Wt | 328.75 | |
| Formula | C17H13ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sileikyte J, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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