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ML406

Chemical Structure : ML406

CAS No.: 774589-47-8

ML406 (ML-406)

Catalog No.: PC-62126Not For Human Use, Lab Use Only.

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD.
ML406 exhibits WT M. tb (H37Rv) growth inhibition without biotin with an IC50 of 3.2 uM.

Physicochemical Properties

M.Wt 352.39
Formula C20H20N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone

References

1. Casalena D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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