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ML406

Chemical Structure : ML406

CAS No.: 774589-47-8

ML406

Catalog No.: PC-62126Not For Human Use, Lab Use Only.

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD; exhibits WT M. tb (H37Rv) growth inhibition without biotin with an IC50 of 3.2 uM.

Physicochemical Properties

M.Wt 352.39
Formula C20H20N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone

References

1. Casalena D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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