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Chemical Structure : ML67-33
CAS No.: 1443290-89-8
Catalog No.: PC-60191Not For Human Use, Lab Use Only.
ML67-33 is a low micromolar (EC50=9.7 uM, K2P2.1), selective activator of temperature- and mechano-sensitive K2P potassium channels.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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ML67-33 is a low micromolar (EC50=9.7 uM, K2P2.1), selective activator of temperature- and mechano-sensitive K2P potassium channels.
ML67-33 shows little or no activity against K2P5.1, K2P3.1, K2P9.1, K2P18.1 and Kv7.2 (>100 uM).
ML67-33 reversibly increases channel currents by activating the extracellular selectivity filter-based C-type gate that forms the core gating apparatus on which a variety of diverse modulatory inputs converge.
ML67-33 also is a potent activator of LyPAP and TMEM175-mediated H+ and K+ currents
| M.Wt | 374.27 | |
| Formula | C18H17Cl2N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,7-Dichloro-9,9-dimethyl-10-[2-(1H-tetrazol-5-yl)-ethyl]-9,10-dihydro-acridine |
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1. Bagriantsev SN, et al. ACS Chem Biol. 2013 Aug 16;8(8):1841-51.
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