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MLAF50

Chemical Structure : MLAF50

CAS No.: 1417653-96-3

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MLAF50 (MLAF 50)

Catalog No.: PC-35174Not For Human Use, Lab Use Only.

MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays.
    MLAF50 inhibits chromatin localization of REV1 in cells after damaging DNA.
    MLAF50 binds to the same residues of REV1 UBM2 that interact with ubiquitin, indicating that MLAF50 can compete with the REV1 UBM2-ubiquitin interaction orthosterically.

    Physicochemical Properties

    M.Wt 510.066
    Formula C15H12I2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(3-(4-hydroxyphenoxy)-2,4-diiodophenyl)propanoic acid

    References

    1. Vanarotti M, et al. J Mol Biol. 2018 Jun 2. pii: S0022-2836(18)30553-9.

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