Chemical Structure : MLKL inhibitor P28
CAS No.:
MLKL inhibitor P28
Catalog No.: PC-21159Not For Human Use, Lab Use Only.
MLKL inhibitor P28 is a potent inhibitor of necroptosis via MLKL inhibition (EC50=10.3 uM), blocks oligomerization and translocation of MLKL.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MLKL inhibitor P28 is a potent inhibitor of necroptosis via MLKL inhibition (EC50=10.3 uM), blocks oligomerization and translocation of MLKL.
MLKL inhibitor P28 is more potent than Necrosulfonamide (NSA, Cat#PC-42202) in preventing cell death after exposure to necroptotic stimuli at a concentration of 0.1 μM.
MLKL inhibitor P28 (3 uM) inhibited the expression of α-SMA, collagen-1, CXCL1/CXCL2, MLKL, and ICAM1 in HSC-LX2 cells.
MLKL inhibitor P28 suppressed TSZ-induced cytokine and chemokine production in monocytes.
MLKL inhibitor P28 reduced the expression of ICAM1 and CXCL1/2, which operate via a pathway different from the conventional necroptosis pathway.
Unlike the necrosulfonamide treatment, the P28 treatment did not induce cytotoxicity.
Physicochemical Properties
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M.Wt
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394.39
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Formula
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C20H18N4O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl (E)-3-(3-(3-(3-hydroxyphenyl)prop-2-yn-1-yl)-1,7-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)acrylate
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References
1. Ju Hee Oh, et al. ACS Pharmacology & Translational Science, 2023.
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