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MLN-4760

Chemical Structure : MLN-4760

CAS No.: 305335-31-3

MLN-4760 (MLN4760, MLN 4760)

Catalog No.: PC-35972Not For Human Use, Lab Use Only.

MLN-4760 (MLN4760) is a potent, selective inhibitor of angiotensin-converting enzyme (ACE)-related carboxypeptidase ACE2 with IC50 of 0.44 nM (hACE2).

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Biological Activity

MLN-4760 (MLN4760) is a potent, selective inhibitor of angiotensin-converting enzyme (ACE)-related carboxypeptidase ACE2 with IC50 of 0.44 nM (hACE2).
MLN-4760 displays >5,000-fold selectivity over related enzymes including human testicular ACE (IC50>100 uM) and bovine carboxypeptidase A (IC50=27 uM).
MLN-4760 exacerbated the Ang II-dependent formation of ROS and abolished the generation of Ang-(1-7) from Ang II.
MLN-4760 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats.

Physicochemical Properties

M.Wt 428.31
Formula C19H23Cl2N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol4-yl]-ethylamino]-4-methylpentanoic acid

References

1. Towler P, et al. J Biol Chem. 2004 Apr 23;279(17):17996-8007.

2. Dales NA, et al. J Am Chem Soc. 2002 Oct 9;124(40):11852-3.

3. Ye M, et al. Hypertension. 2012 Sep;60(3):730-40.

4. Joshi S, et al. Eur J Pharmacol. 2016 Mar 5;774:25-33.

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