Chemical Structure : MLN-4760
CAS No.: 305335-31-3
Catalog No.: PC-35972Not For Human Use, Lab Use Only.
MLN-4760 (MLN4760) is a potent, selective inhibitor of angiotensin-converting enzyme (ACE)-related carboxypeptidase ACE2 with IC50 of 0.44 nM (hACE2).
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MLN-4760 (MLN4760) is a potent, selective inhibitor of angiotensin-converting enzyme (ACE)-related carboxypeptidase ACE2 with IC50 of 0.44 nM (hACE2).
MLN-4760 displays >5,000-fold selectivity over related enzymes including human testicular ACE (IC50>100 uM) and bovine carboxypeptidase A (IC50=27 uM).
MLN-4760 exacerbated the Ang II-dependent formation of ROS and abolished the generation of Ang-(1-7) from Ang II.
MLN-4760 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats.
M.Wt | 428.31 | |
Formula | C19H23Cl2N3O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol4-yl]-ethylamino]-4-methylpentanoic acid |
1. Towler P, et al. J Biol Chem. 2004 Apr 23;279(17):17996-8007.
2. Dales NA, et al. J Am Chem Soc. 2002 Oct 9;124(40):11852-3.
3. Ye M, et al. Hypertension. 2012 Sep;60(3):730-40.
4. Joshi S, et al. Eur J Pharmacol. 2016 Mar 5;774:25-33.
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