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You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Polo-like Kinase (PLK)-MLN0905
MLN0905

Chemical Structure : MLN0905

CAS No.: 1228960-69-7

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MLN0905 (MLN-0905)

Catalog No.: PC-24927Not For Human Use, Lab Use Only.

MLN0905 is a potent, selective and orally bioavailable inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 2 nM.

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10 mg $148 In stock
25 mg $258 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MLN0905 is a potent, selective and orally bioavailable inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 2 nM.
MLN0905 has EC30 of 9 nM in mitotic index assay and EC50 of 29 nM in Cdc25C-T96 cell-based assay.
MLN0905 demonstrated prolonged mitotic arrest after oral administration of 12c to tumor bearing nude mice.

Physicochemical Properties

M.Wt 486.56
Formula C24H25F3N6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((5-(3-(Dimethylamino)propyl)-2-methylpyridin-3-yl)amino)-9-(trifluoromethyl)-5,7-dihydro-6H-benzo[b]pyrimido[4,5-d]azepine-6-thione

References

1. Duffey MO, et al. J Med Chem. 2012 Jan 12;55(1):197-208.

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