MLS8091 | HCMV inhibitor | Probechem Biochemicals

Chemical Structure : MLS8091

MLS8091 (MLS-8091)

Catalog No.: PC-27314Not For Human Use, Lab Use Only.

MLS8091 is a highly selective human cytomegalovirus (HCMV) inhibitor with EC50 of 0.4 uM against HCMV Towne strain, targets HCMV helicase-primase (H/P) complex.

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Biological Activity

MLS8091 is a highly selective human cytomegalovirus (HCMV) inhibitor with EC50 of 0.4 uM against HCMV Towne strain, targets HCMV helicase-primase (H/P) complex.
MLS8091 shows no inhibition of herpes simplex 1 or 2 (HSV-1, 2), or mouse CMV (MCMV), and moderate activity against guinea pig CMV (GPCMV), with EC50 values of 3.6 ± 0.4 µM and 3.1 ± 0.1 µM in plaque and PCR assays, respectively.

Physicochemical Properties

M.Wt	420.51
Formula	C21H16N4O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-3-(thiophen-2-ylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine

References

1. Kapoor A, et al. Antimicrob Agents Chemother. 2026 Jul 13:e0197725.

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MLS8091 (MLS-8091)

Biological Activity

Physicochemical Properties

References

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