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Chemical Structure : MLT-231
Catalog No.: PC-49480Not For Human Use, Lab Use Only.
MLT-231 (MLT231) is a highly potent, selective, allosteric MALT1 inhibitor with biochemical IC50 of 9 nM, inhibits MALT1 cleavage of the BCL10 substrate with IC50 of 0.16 uM.
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MLT-231 (MLT231) is a highly potent, selective, allosteric MALT1 inhibitor with biochemical IC50 of 9 nM, inhibits MALT1 cleavage of the BCL10 substrate with IC50 of 0.16 uM.
MLT-231 exhibited high MALT1 selectivity over other proteases.
MLT-231 inhibited cellular proliferation (low micromolar range) and cleavage of MALT1 substrates in ABC-DLBCL.
MLT-231 (100 mg/kg) dose-dependently reduced the anti-DNP IgM and IgG responses induced by 2,4-dinitrophenol (DNP) in mice, blocked T cell-dependent B cell responses.
MLT-231 (100 mg/kg, oral bid schedule for 2 weeks) exhibited antitumor efficacy in OCI-Ly10 ABC-DLBCL type xenograft models.
| M.Wt | 469.853 | |
| Formula | C19H19ClF3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carole Pissot Soldermann, et al. J Med Chem. 2020 Dec 10;63(23):14576-14593.
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