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Chemical Structure : MLT-747
Catalog No.: PC-36043Not For Human Use, Lab Use Only.
MLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM.
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MLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM.
MLT-747 binds MALT1 in the allosteric Trp580 pocket, reversibly binds and stabilizes human mutant MALT1-W580S in vitro and in MALT1mut/mut B cells, inhibits MALT1 peptide cleavage.
| M.Wt | 478.334 | |
| Formula | C20H21Cl2N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Quancard J, et al. Nat Chem Biol. 2019 Jan 28. doi: 10.1038/s41589-018-0222-1.
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