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Chemical Structure : MLT-827
Catalog No.: PC-49481Not For Human Use, Lab Use Only.
MLT-827 is a potent and selective inhibitor of MALT1 paracaspase activity with IC50 of 5 nM.
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MLT-827 is a potent and selective inhibitor of MALT1 paracaspase activity with IC50 of 5 nM.
MLT-827 blocks MALT1 substrate cleavage in human CD3+ T lymphocytes stimulated with PMA/Ionomycin in a concentration-dependent manner.
MLT-827 selectively blocks the proteolytic function of MALT1 but does not prevent its scaffolding function, required to engage IκK and JNK signaling.
MLT-827 blocks the pro-survival program triggered by TCR ligation and limits cell expansion.
MLT-827 had only minimal impact on T-cell activation, but profoundly impacted cytokine production, in particular IL-2 and TNF-α.
MLT-827 reduces NF-κB transcriptional activation but has no impact on NF-AT or AP1.
| M.Wt | 452.90 | |
| Formula | C22H21ClN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bardet M, et al. Immunol Cell Biol. 2018 Jan;96(1):81-99.
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