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Chemical Structure : MLT-943
CAS No.: 1832576-04-1
Catalog No.: PC-49483Not For Human Use, Lab Use Only.
MLT-943 is a potent and selective MALT1 protease inhibitor with IC50 of 40 nM in IL-2 reporter gene assay (Jurkat T cells), inhibits human PBMC IL-2 release with IC50 of 74 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $498 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | Get quote |
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MLT-943 is a potent and selective MALT1 protease inhibitor with IC50 of 40 nM in IL-2 reporter gene assay (Jurkat T cells), inhibits human PBMC IL-2 release with IC50 of 74 nM.
MLT-943 displayed high selectivity against a range of proteases and other selected off-target panels.
MLT-943 (10 mg/kg QD p.o.) in the rat collagen-induced arthritis model suppressed anti-collagen antibody production, reduced Tregs in rat and mouse.
| M.Wt | 414.773 | |
| Formula | C16H14ClF3N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)-3-(2-(trifluoromethyl)pyridin-4-yl)urea |
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1. Patent WO2015/181747.
2. Kea Martin, et al. Front Immunol. 2020 Apr 30;11:745.
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