Chemical Structure : MM-129
CAS No.:
2426541-31-1
MM-129
(MM129)
Catalog No.: PC-26319Not For Human Use, Lab Use Only.
MM-129 (MM129) is a novel inhibitor targeting BTK/PI3K/AKT/mTOR and PD-L1, inhibits intracellular pathways promoting tumorigenesis with a simultaneous reduction of PD-L1 expression.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MM-129 (MM129) is a novel inhibitor targeting BTK/PI3K/AKT/mTOR and PD-L1, inhibits intracellular pathways promoting tumorigenesis with a simultaneous reduction of PD-L1 expression.
MM-129 significantly reduced tumor growth in mice challenged with DLD-1 and HT-29 cells.
MM-129 induces apoptosis through phosphatidylserine externalisation and loss of mitochondrial membrane potential.
MM-129 effectively inhibits tumour development in zebrafish embryo xenograft model, shows a markedly synergistic anticancer effect when used in combination with 5-FU.
MM-129 possesses antitumor activity in xenograft mouse models of colon cancer.
Physicochemical Properties
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M.Wt
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459.44
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Formula
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C17H17N9O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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L-Proline, 4-hydroxy-1-[[4-(8-methyl-6H-pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazin-6-yl)phenyl]sulfonyl]-, methyl ester
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References
1. Hermanowicz JM, et al. Pharmaceutics. 2021 Aug 7;13(8):1222.
2. Hermanowicz JM, et al. Cancers (Basel). 2021 Jun 26;13(13):3203.
3. Hermanowicz JM, et al. J Enzyme Inhib Med Chem. 2021 Dec;36(1):535-548.
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