MMH2 | BRD4 degrader | Probechem Biochemicals

Chemical Structure : MMH2

MMH2 (BRD4 degrader MMH2)

Catalog No.: PC-22823Not For Human Use, Lab Use Only.

MMH2 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16 (BRD4BD2, DC50=1 nM, Dmax=95%), functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4.

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Biological Activity

Physicochemical Properties

M.Wt	527.66
Formula	C25H29N5O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl (S)-2-(2,3,9-trimethyl-4-(4-(vinylsulfonamido)phenyl)-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

References

1. Li YD, et al. Nat Chem Biol. 2024 Jul 29. doi: 10.1038/s41589-024-01668-4.

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MMH2 (BRD4 degrader MMH2)

Biological Activity

Physicochemical Properties

References

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