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Chemical Structure : MMV390048
CAS No.: 1314883-11-8
Catalog No.: PC-61691Not For Human Use, Lab Use Only.
MMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain).
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MMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain); blocks all life cycle stages of the malaria parasite, exhibits full chemoprotection, delays relapse in a Plasmodium cynomolgi monkey model.
Parasite Infection
Phase 2 Clinical
| M.Wt | 393.3842 | |
| Formula | C18H14F3N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(4-(methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine |
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1. Paquet T, et al. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.
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