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MMV390048

Chemical Structure : MMV390048

CAS No.: 1314883-11-8

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MMV390048 (MMV 048, MMV390048)

Catalog No.: PC-61691Not For Human Use, Lab Use Only.

MMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MMV390048 is a novel potent Plasmodium PI4K inhibitor with IC50 of 28 nM against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain).
MMV390048 blocks all life cycle stages of the malaria parasite, exhibits full chemoprotection.
MMV390048 delays relapse in a Plasmodium cynomolgi monkey model.

Physicochemical Properties

M.Wt 393.3842
Formula C18H14F3N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(4-(methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine

References

1. Paquet T, et al. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.

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