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Chemical Structure : MN551
Catalog No.: PC-21790Not For Human Use, Lab Use Only.
MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.
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MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.
MN551 selectively reacts with SOCS2 and CISH over other SOCS family members.
MN551 shows low cellular permeability.
MN551 blocks substrate interaction by covalently modifying Cys111 inside the cell.
| M.Wt | 563.90 | |
| Formula | C25H24ClFN3O7P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarath Ramachandran, et al. Nat Commun. 2023 Oct 10;14(1):6345.
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