MN551 | SOCS2 inhibitor | Probechem Biochemicals

Chemical Structure : MN551

MN551 (MN 551, MN-551)

Catalog No.: PC-21790Not For Human Use, Lab Use Only.

MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.

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Biological Activity

MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.
MN551 selectively reacts with SOCS2 and CISH over other SOCS family members.
MN551 shows low cellular permeability.
MN551 blocks substrate interaction by covalently modifying Cys111 inside the cell.

Physicochemical Properties

M.Wt	563.90
Formula	C25H24ClFN3O7P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	FC1=CC=C(CC(N[C@H](C(NCC2=CC=CC(NC(Cl)=O)=C2)=O)CC3=CC=C(OP(O)(O)=O)C=C3)=O)C=C1

References

1. Sarath Ramachandran, et al. Nat Commun. 2023 Oct 10;14(1):6345.

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MN551 (MN 551, MN-551)

Biological Activity

Physicochemical Properties

References

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