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MN551

Chemical Structure : MN551

CAS No.:

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MN551 (MN 551, MN-551)

Catalog No.: PC-21790Not For Human Use, Lab Use Only.

MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.
    MN551 selectively reacts with SOCS2 and CISH over other SOCS family members.
    MN551 shows low cellular permeability.
    MN551 blocks substrate interaction by covalently modifying Cys111 inside the cell.

    Physicochemical Properties

    M.Wt 563.90
    Formula C25H24ClFN3O7P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(3-((3-((chlorocarbonyl)amino)benzyl)amino)-2-(2-(4-fluorophenyl)acetamido)-3-oxopropyl)phenyl dihydrogen phosphate

    References

    1. Sarath Ramachandran, et al. Nat Commun. 2023 Oct 10;14(1):6345.

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