MN714 | SOCS2 inhibitor | Probechem Biochemicals

Chemical Structure : MN714

MN714 (MN 714, MN-714)

Catalog No.: PC-21791Not For Human Use, Lab Use Only.

MN714 is a cell-premeable prodrug of MN551 containing a pivaloyloxymethyl (POM) and covalent inhibitor of E3 ligase suppressor of cytokine signaling 2 (SOCS2).

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Biological Activity

MN714 is a cell-premeable prodrug of MN551 containing a pivaloyloxymethyl (POM) and covalent inhibitor of E3 ligase suppressor of cytokine signaling 2 (SOCS2).
MN714 (1 uM and 10 uM) shows a dose-dependent increase in levels of SOCS2 modification.
MN714 (10 uM) shows a complete saturation of Cys111 with no detectable levels of unmodified Cys111 in K562 cells.

Physicochemical Properties

M.Wt	792.19
Formula	C37H44ClFN3O11P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	FC1=CC=C(CC(N[C@H](C(NCC2=CC=CC(NC(Cl)=O)=C2)=O)CC3=CC=C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C=C3)=O)C=C1

References

1. Sarath Ramachandran, et al. Nat Commun. 2023 Oct 10;14(1):6345.

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MN714 (MN 714, MN-714)

Biological Activity

Physicochemical Properties

References

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