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Chemical Structure : MNKI-19
Catalog No.: PC-63078Not For Human Use, Lab Use Only.
MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively.
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MNKI-19 is a potent and dual-specific MAPK-interacting kinase (MNK) inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively.
MNKI-19 only displays moderate activity against Pim-1 (Ki=2.35 uM) in a panel of upstream activating kinases of Mnks, including B-Raf, MAPK1, MAPK2, Akt1, PI3K, p38α, and mTOR.
MNKI-19 inhibits the phosphorylation of eIF4E and 4E-BP1, arrests cancer cells in the G1 phase and induce apoptosis in FLT3-ITD expressed AML cells.
| M.Wt | 361.391 | |
| Formula | C17H16FN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9.
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