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MNKI-85

Chemical Structure : MNKI-85

CAS No.: 1812885-57-6

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MNKI-85 (MNKI85)

Catalog No.: PC-63077Not For Human Use, Lab Use Only.

MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D.
    MNKI-85 effectively inhibits the growth of AML cells that possess an M5 subtype with FLT3-internal tandem duplication mutation.
    MNKI-85 is a powerful pharmacologic tool in studying the Mnk2/eIF4E-mediated tumorigenic mechanism.

    Physicochemical Properties

    M.Wt 418.487
    Formula C20H23FN4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[[4-Fluoro-2-(1-methylethoxy)phenyl]amino]-N-(2-methoxyethyl)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide

    References

    1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9.

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