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Chemical Structure : MNKI-85
Catalog No.: PC-63077Not For Human Use, Lab Use Only.
MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D.
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MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D.
MNKI-85 effectively inhibits the growth of AML cells that possess an M5 subtype with FLT3-internal tandem duplication mutation.
MNKI-85 is a powerful pharmacologic tool in studying the Mnk2/eIF4E-mediated tumorigenic mechanism.
| M.Wt | 418.487 | |
| Formula | C20H23FN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9.
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