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Chemical Structure : MNKI-8e
Catalog No.: PC-63074Not For Human Use, Lab Use Only.
MNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM, displays >34-fold and 4-fold over CDK2 (Ki>10 uM) and CDK9 (Ki=1.66 uM).
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MNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM, displays >34-fold and 4-fold over CDK2 (Ki>10 uM) and CDK9 (Ki=1.66 uM).
MNKI-8e potently inhibits leukemia cells with GI50 of 1.23-7.36 uM (MV4-11 GI50=1.32 uM and KG-1 GI50=1.23 uM).
MNKI-8e blocks phosphorylation of eIF4E, downregulates anti-apoptotic protein Mcl-1 and induces apoptosis in AML cells.
MNKI-8e suppresses the Ara-C-induced MAPK activity and enhances apoptosis in MV4-11 cells.
| M.Wt | 358.416 | |
| Formula | C17H18N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Diab S, et al. ChemMedChem. 2014 May;9(5):962-72.
2. Li P, et al. Oncotarget. 2016 Aug 30;7(35):56811-56825.
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