Catalog No.: PC-63074Not For Human Use, Lab Use Only.
MNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM, displays >34-fold and 4-fold over CDK2 (Ki>10 uM) and CDK9 (Ki=1.66 uM).
MNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM, displays >34-fold and 4-fold over CDK2 (Ki>10 uM) and CDK9 (Ki=1.66 uM).
MNKI-8e potently inhibits leukemia cells with GI50 of 1.23-7.36 uM (MV4-11 GI50=1.32 uM and KG-1 GI50=1.23 uM).
MNKI-8e blocks phosphorylation of eIF4E, downregulates anti-apoptotic protein Mcl-1 and induces apoptosis in AML cells.
MNKI-8e suppresses the Ara-C-induced MAPK activity and enhances apoptosis in MV4-11 cells.
