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Chemical Structure : MNK inhibitor 9
Catalog No.: PC-61145Not For Human Use, Lab Use Only.
MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM).
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MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM).
MNK inhibitor 9 displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM.
MNK inhibitor 9 inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM.
MNK inhibitor 9 has good solubility and permeability, and is a suitable in vivo tool compound.
| M.Wt | 471.569 | |
| Formula | C25H29N9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Han W, et al. J Med Chem. 2016 Apr 14;59(7):3034-45.
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