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MNK inhibitor 9

Chemical Structure : MNK inhibitor 9

CAS No.: 1889336-59-7

MNK inhibitor 9

Catalog No.: PC-61145Not For Human Use, Lab Use Only.

MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM).

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    Biological Activity

    MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM).
    MNK inhibitor 9 displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM.
    MNK inhibitor 9 inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM.
    MNK inhibitor 9 has good solubility and permeability, and is a suitable in vivo tool compound.

    Physicochemical Properties

    M.Wt 471.569
    Formula C25H29N9O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-2-(5-Amino-6-(1-methyl-7-(3-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)pyrazin-2-yl)-N,N-dimethylisonicotinamide

    References

    1. Han W, et al. J Med Chem. 2016 Apr 14;59(7):3034-45.

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