Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MONNA
CAS No.: 1572936-83-4
Catalog No.: PC-38479Not For Human Use, Lab Use Only.
MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1).
MONNA displays >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR.
MONNA concentration-dependently relax rodent resistance arteries.
MONNA attenuated 5-HT/U46619-induced contractions, also increased coronary flow in Langendorff perfused rat heart preparations, in rat coronary arteries.
| M.Wt | 338.319 | |
| Formula | C18H14N2O5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid |
|
1. Boedtkjer DM, et al. Br J Pharmacol. 2015 Aug;172(16):4158-72.
2. Ru F, et al. J Physiol. 2017 Jun 1;595(11):3651-3666.
3. Askew Page HR, et al. Br J Pharmacol. 2019 Jun;176(11):1635-1648.
4. Soo-Jin Oh, et al. Mol Pharmacol. 2013 Nov;84(5):726-35.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
