You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Chloride Channel-MONNA
MONNA

Chemical Structure : MONNA

CAS No.: 1572936-83-4

MONNA (TMEM16A inhibitor MONNA)

Catalog No.: PC-38479Not For Human Use, Lab Use Only.

MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1).

Packing Price Stock Quantity
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1).
MONNA displays >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR.
MONNA concentration-dependently relax rodent resistance arteries.
MONNA attenuated 5-HT/U46619-induced contractions, also increased coronary flow in Langendorff perfused rat heart preparations, in rat coronary arteries.

Physicochemical Properties

M.Wt 338.319
Formula C18H14N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid

References

1. Boedtkjer DM, et al. Br J Pharmacol. 2015 Aug;172(16):4158-72.

2. Ru F, et al. J Physiol. 2017 Jun 1;595(11):3651-3666.

3. Askew Page HR, et al. Br J Pharmacol. 2019 Jun;176(11):1635-1648.

4. Soo-Jin Oh, et al. Mol Pharmacol. 2013 Nov;84(5):726-35.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: