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Chemical Structure : MONNA
CAS No.: 1572936-83-4
Catalog No.: PC-38479Not For Human Use, Lab Use Only.
MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1).
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|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1).
MONNA displays >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR.
MONNA concentration-dependently relax rodent resistance arteries.
MONNA attenuated 5-HT/U46619-induced contractions, also increased coronary flow in Langendorff perfused rat heart preparations, in rat coronary arteries.
| M.Wt | 338.319 | |
| Formula | C18H14N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid |
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1. Boedtkjer DM, et al. Br J Pharmacol. 2015 Aug;172(16):4158-72.
2. Ru F, et al. J Physiol. 2017 Jun 1;595(11):3651-3666.
3. Askew Page HR, et al. Br J Pharmacol. 2019 Jun;176(11):1635-1648.
4. Soo-Jin Oh, et al. Mol Pharmacol. 2013 Nov;84(5):726-35.
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