MONNA | TMEM16A inhibitor | Probechem Biochemicals

Chemical Structure : MONNA

CAS No.: 1572936-83-4

MONNA (TMEM16A inhibitor MONNA)

Catalog No.: PC-38479Not For Human Use, Lab Use Only.

MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1).

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25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1).
MONNA displays >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR.
MONNA concentration-dependently relax rodent resistance arteries.
MONNA attenuated 5-HT/U46619-induced contractions, also increased coronary flow in Langendorff perfused rat heart preparations, in rat coronary arteries.

Physicochemical Properties

M.Wt	338.319
Formula	C18H14N2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid

References

1. Boedtkjer DM, et al. Br J Pharmacol. 2015 Aug;172(16):4158-72.

2. Ru F, et al. J Physiol. 2017 Jun 1;595(11):3651-3666.

3. Askew Page HR, et al. Br J Pharmacol. 2019 Jun;176(11):1635-1648.

4. Soo-Jin Oh, et al. Mol Pharmacol. 2013 Nov;84(5):726-35.

MONNA (TMEM16A inhibitor MONNA)

Biological Activity

Physicochemical Properties

References

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