MP-A08 |CAS:219832-49-2 Probechem Biochemicals

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Chemical Structure : MP-A08

CAS No.: 219832-49-2

MP-A08 (MP A08)

Catalog No.: PC-45716Not For Human Use, Lab Use Only.

MP-A08 is a first-in-class, highly selective, ATP competitive sphingosine kinase (SphK) inhibitor (Ki of 6.9/27 uM for SK2/SK1).

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10 mg	$88	In stock
25 mg	$148	In stock
50 mg	$248	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MP-A08 is a first-in-class, highly selective, ATP competitive sphingosine kinase (SphK) inhibitor (Ki of 6.9/27 uM for SK2/SK1).
MP-A08 inhibits S1P production and increases pro-apoptotic sphingolipids in Jurkat cells.
MP-A08 reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis.

Physicochemical Properties

M.Wt	519.6351
Formula	C27H25N3O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-

References

1. Pitman MR, et al. Oncotarget. 2015 Mar 30;6(9):7065-83.

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MP-A08 (MP A08)

Biological Activity

Physicochemical Properties

References

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