Catalog No.: PC-35617Not For Human Use, Lab Use Only.
MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation.
MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation.
MP-HJ-1b shows activities against a panel of more than 1000 human cancer cell lines with a wide variety of tissue origins, also induces the spike-like conformation of microtubules in vitro and in vivo, which is different from typical microtubule modulators.
MP-HJ-1b exhibits an interesting property of general cytotoxicity instead of Ras-mutant-specific killing (A549 KRAS-G12S, IC50=0.04 uM).
MPHJ-1b displayed favorable pharmacological properties for overcoming tumor MDR both in vitro and in vivo.
