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MP135

Chemical Structure : MP135

CAS No.: 2677687-49-7

MP135 (MP-135)

Catalog No.: PC-49035Not For Human Use, Lab Use Only.

MP135 is a potent, μ-δ opioid receptor heteromer-selective agonist with EC50 of 0.8 nM in GTPγS assays, shows functional selectivity for μ-δ heteromers over homomeric μOR and δOR and low β-arrestin2 recruitment activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MP135 is a potent, μ-δ opioid receptor heteromer-selective agonist with EC50 of 0.8 nM in GTPγS assays, shows functional selectivity for μ-δ heteromers over homomeric μOR and δOR and low β-arrestin2 recruitment activity.
    MP135 is a poor recruiter of β-arrestin2 at μ-δ heteromers (EC50=162 nM).
    MP135 shows selectivity for μ-δ heteromers both ex vivo as well as in vivo and retains in vivo antinociceptive efficacy similar to morphine in rodents.

    Physicochemical Properties

    M.Wt 515.673
    Formula C32H38FN3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(N-Benzylpropionamido)-N-(3-fluorophenethyl)-1-phenethyl-piperidine-4-carboxamide

    References

    1. Faouzi A, et al. J Med Chem. 2020 Nov 25;63(22):13618-13637.

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