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Chemical Structure : MP135
Catalog No.: PC-49035Not For Human Use, Lab Use Only.
MP135 is a potent, μ-δ opioid receptor heteromer-selective agonist with EC50 of 0.8 nM in GTPγS assays, shows functional selectivity for μ-δ heteromers over homomeric μOR and δOR and low β-arrestin2 recruitment activity.
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MP135 is a potent, μ-δ opioid receptor heteromer-selective agonist with EC50 of 0.8 nM in GTPγS assays, shows functional selectivity for μ-δ heteromers over homomeric μOR and δOR and low β-arrestin2 recruitment activity.
MP135 is a poor recruiter of β-arrestin2 at μ-δ heteromers (EC50=162 nM).
MP135 shows selectivity for μ-δ heteromers both ex vivo as well as in vivo and retains in vivo antinociceptive efficacy similar to morphine in rodents.
| M.Wt | 515.673 | |
| Formula | C32H38FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Faouzi A, et al. J Med Chem. 2020 Nov 25;63(22):13618-13637.
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