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Chemical Structure : MPD2
Catalog No.: PC-22155Not For Human Use, Lab Use Only.
MPD2 is a first-in-class PROTAC degrader of SARS-CoV-2 MPro, effectively reduces MPro protein levels in 293T cells with DC50 of 296 nM on a time-dependent, CRBN-mediated, and proteasome-driven mechanism.
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MPD2 is a first-in-class PROTAC degrader of SARS-CoV-2 MPro, effectively reduces MPro protein levels in 293T cells with DC50 of 296 nM on a time-dependent, CRBN-mediated, and proteasome-driven mechanism.
MPD2 exhibits promising antiviral activity against various SARS-CoV-2 strains and exhibiting enhanced potency against nirmatrelvir-resistant viruses.
| M.Wt | 973.13 | |
| Formula | C51H68N6O13 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alugubelli YR, et al. J Med Chem. 2024 Apr 12. doi: 10.1021/acs.jmedchem.3c02416.
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