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MPL-5821

Chemical Structure : MPL-5821

CAS No.: 1602492-16-9

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MPL-5821 (MPL5821)

Catalog No.: PC-24996Not For Human Use, Lab Use Only.

MPL-5821 is a potent and myeloid selective p38α MAPK inhibitor, could be hydrolysied by hCE-1 to active form MPL-5822.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MPL-5821 is a potent and myeloid selective p38α MAPK inhibitor, could be hydrolysied by hCE-1 to active form MPL-5822.
MPL-5821 not only inhibits IL-10 but also enhances LPS stimulated IL-12p70 and in contrast to conventional p38 MAPK inhibitors.
MPL-5821 potently inhibited the R848 induced IL-10 production, whilst sparing T-cell functionality.

Physicochemical Properties

M.Wt 533.52
Formula C27H27F4N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-butyl (4-(6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl)-3,5-difluorophenethyl)-L-alaninate

References

1. Lund A, et al. Mol Immunol. 2025 Jul;183:145-155.

2. David Moffat, et al. Cancer Res (2018) 78 (13_Supplement): 3877.

3. Charlton, Michael H, et al. MedChemComm (2012), 3(9), 1070-1076.

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