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Chemical Structure : MPO-0144
Catalog No.: PC-49237Not For Human Use, Lab Use Only.
MPO-0144 (MPO 0144) is a potent, selective mPGES-1 inhibitor (PGE2 IC50=41.77 nM, mPGES-1 IC50=1.16 nM).
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MPO-0144 (MPO 0144) is a potent, selective mPGES-1 inhibitor (PGE2 IC50=41.77 nM, mPGES-1 IC50=1.16 nM).
MPO-0144 exhibits potent neuroprotection (ED50=3.0 nM) against 6-OHDA-induced in PC12 cells without significant neurotoxicity (IC50>10 uM).
MPO-0144 (1 mg/kg/day, for 7 days, i.p.) ameliorated motor impairments and dopaminergic neuronal damage in 6-OHDA-induced mouse model of Parkinson's disease (PD).
| M.Wt | 543.415 | |
| Formula | C26H20Cl2N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Seyoung Yang, et al. Bioorg Med Chem Lett. 2022 Aug 2;74:128920.
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