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MPO-0144

Chemical Structure : MPO-0144

CAS No.: 2766397-73-1

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MPO-0144 (MPO 0144)

Catalog No.: PC-49237Not For Human Use, Lab Use Only.

MPO-0144 (MPO 0144) is a potent, selective mPGES-1 inhibitor (PGE2 IC50=41.77 nM, mPGES-1 IC50=1.16 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MPO-0144 (MPO 0144) is a potent, selective mPGES-1 inhibitor (PGE2 IC50=41.77 nM, mPGES-1 IC50=1.16 nM).
    MPO-0144 exhibits potent neuroprotection (ED50=3.0 nM) against 6-OHDA-induced in PC12 cells without significant neurotoxicity (IC50>10 uM).
    MPO-0144 (1 mg/kg/day, for 7 days, i.p.) ameliorated motor impairments and dopaminergic neuronal damage in 6-OHDA-induced mouse model of Parkinson's disease (PD).

    Physicochemical Properties

    M.Wt 543.415
    Formula C26H20Cl2N2O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(benzyloxy)phenyl 2-(3-chlorophenyl)-1-((4-chlorophenyl)sulfonyl)hydrazine-1-carboxylate

    References

    1. Seyoung Yang, et al. Bioorg Med Chem Lett. 2022 Aug 2;74:128920.

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